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Watch Carefully (one)pentobarbital will lower the extent or impact of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to a minimize in fentanyl plasma concentrations, insufficient efficacy or, perhaps, improvement of a withdraw

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